Beiträge in Fachzeitschriften

2012

C. Planchette^a; A.L. Biance^b; E. Lorenceau^b. Transition of liquid marble impacts onto solid surfaces. - in: Euro Physics Letters (Jan 4, 2012)
a Research Center Pharmaceutical Engineering, Graz, Austria
b Laboratoire Navier, Universite Paris-Est, Champs-sur-Marne, France

C. Planchette^a; E. Lorenceau^a; A.-L. Biance^b. Surface wave on a particle raft. - in: Soft Matter (2012)
a Universite Paris-Est, France
b Universite Claude Bernard Lyon, France

G. Toschkoff^a; D. Suzzi^a; W. Tritthart^b; F. Reiter^b; M. Schlingmann^b; J.G: Khinast^a,c. Detailed Analysis of Air Flow and Spray Loss in a Pharmaceutical Coating Process. - in: AIChE Journal 58/2 (2012) 399-411 (Jun, 16 2011)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b G.L. Pharma GmbH, Lannach, Austria
c Institute for Particle and Process Technology, Graz, Austria

A.Hodzic^a; M. Llusa^a; N. Heigl^a; W. Tritthart^d; S.D. Fraser^a; P.  Laggner^b; J.G.Khinast^a,c. Effect of process variables on the Small-Angle X-Ray Scattering patterns of powders, granules and pharmaceutical tablets. - in: Powder Technology (Feb 3, 2012)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Graz, Austria
c Institute for Particle and Process Technology, Graz, Austria
d G.L. Pharma GmbH, Lannach, Austria

E.M. Littringer^a; A. Mescher^b; S. Eckhard^c; H. Schröttner^d; C. Langes^e; M. Fries^c; U. Griesser^e; P. Walzel^b; N.A. Urbanetz^a. Spray drying of mannitol as a drug carrier – The impact of process parameters on the product properties. – in: Drying Technology 30/1 (2012) (Nov 7, 2011)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria,
b Department of Biochemical and Chemical Engineering, Technische Universitaet Dortmund, Germany,
c Fraunhofer Institute for Ceramic Technologies and Systems, Dresden, Germany,
d Austrian Centre for Electron Microscopy and Nanoanalysis, Graz University of Technology, Austria
e Institute of Pharmacy, Pharmaceutical Technology, University of Innsbruck, Austria

S. Liebminger^a; M. Aichner^a,b; L. Oberauner^a,b; M. Fürnkranz^b; M. Cardinale^b; G. Berg^b. A new textile-based approach to assess the antimicrobial activity of volatiles. – in: Journal of Textile Research (2012) (Dec 1, 2011)
aResearch Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Environmental Biotechnology, Graz University of Technology, Graz, Austria

B. Remy^a,c; J.G. Khinast^b; B.J. Glasser^c. Wet granular flows in a bladed mixer: Experiments and simulations of monodisperse spheres. – in: Chemical Engineering Science (2012)
a Late Stage Chemical Development, Bristol-Myers Squibb Co., NJ, USA
b Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
c Department of Chemical and Biochemical Engineering, Rutgers University, NJ, USA

B. Gübitz^a,c; H. Schnedl^d; J.G. Khinast^a,b. A Risk Management Ontology for Quality-by-Design Based on a New Development Approach According GAMP 5.0. – in: Risk Analysis (2012)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
c VTU Engineering GmbH, Grambach, Austria
d THE LIFECYCLE INTELLIGENCE GROUP GmbH, Graz, Austria

D. Suzzi^a; G. Toschkoff^a; S. Radl^a,b; D. Machold^a; S.D. Fraser^a; B.J. Glasser^c; J.G. Khinast^a,b. DEM Simulation of Continuous Tablet Coating: Effects of Tablet Shape and Fill Level on Inter-Tablet Coating Variability. – in: Chemical Engineering Science 69 (2012) 107-121 (Oct 28, 2011)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
c Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, USA

2011

S. Stegemann^a, I. Klebovich^b, I. Antal^b, H. H. Blume^c, K. Magyar^d, G. Németh^e, T. L. Paál^f, W. Stumptner^g, G. Thaler^e, A. Van de Putte^a, V. P. Shah^h: Improved therapeutic entities derived from known generics as an unexplored source of innovative drug products. – in: European Journal of Pharmaceutical Sciences 44 (2011) 447-454 (Nov 20, 2011)
a Capsugel, Bornem, Belgium
b Semmelweis University,Department of Pharmaceutics, Budapest, Hungary
c SocraTec R&D Ltd., Oberursel, Germany
d Hungarian Academy of Science, Budapest, Hungary
e Gedeon Richter PLC., Budapest, Hungary
f University of Szeged, Institute of Drug Regulatory Affairs, Szeged, Hungary
g Research Center Pharmaceutical Engineering Ltd., Graz, Austria
h Pharmaceutical Consultant, North Potomac, MD, USA

E. Roblegg^a,b, S. Schrank^a,b,c, M. Griesbacher^a, S. Radl^c, A. Zimmer^a, J.G. Khinast^b,c: Use of the Direct Compression Aid Ludiflash® for the preparation of pellets via wet extrusion/spheronization. – in: Drug Development and Industrial Pharmacy 37 (2011) 1231-1243 (Oct 2011)
a Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens University, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria
c Institute for Process and Particle Engineering, Graz University of Technology, Austria

S. Radl^a,b; S. Larisegger^b; D. Suzzi^b; J.G. Khinast^a,b. Quantifying Absorption Effects during Hydrogen Peroxide Decontamination. – in: Journal of Pharmaceutical Innovation (2011) 202-216 (Oct 01, 2011)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria

T. Hörmann^a; D. Suzzi^a; J.G. Khinast^a,b. Mixing and Dissolution Processes of Pharmaceutical Bulk Materials in Stirred Tanks: Experimental and Numerical Investigations. – in: Industrial & Engineering Chemistry Research 1 (2011) 12011-12025 (Sep 23, 2011)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria

J. Pardeike^a; D.M. Strohmeier^a,b; N. Schrödl^b; C. Voura^b; M. Gruber^b; J.G. Khinast^b; A. Zimmer^a. Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines. - in: International Journal of Pharmaceutics (Aug 15, 2011)
a Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens Universität Graz, Universitätsplatz 1, 8010 Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 21a/II, 8010 Graz, Austria

D.M. Koller^a; G. Hannesschläger^b; M. Leitner^b; J.G. Khinast^a,c.
Non-destructive analysis of tablet coatings with optical coherence tomography. - in: European Journal of Pharmaceutical Sciences 44 (2011) 142-148 (Jul 20, 2011)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b RECENDT Research Center for Non Destructive Testing GmbH, Linz, Austria
c Institute for Process Engineering, Graz University of Technology, Graz, Austria

S. G. Maas^a; G. Schaldach^b; E.M. Littringer^c; A. Mescher^b; U.J. Griesser^d; D.E. Braun^d; P.E. Walzel^b; N.A. Urbanetz^c. The impact of spray drying outlet temperature on the particle morphology of mannitol. – in: Powder Technology 213 (2011) 27-35 (Jul 19, 2011)
a Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany
b Department of Biochemical and Chemical Engineering, Technische Universitaet Dortmund, Dortmund, Germany
c Research Center Pharmaceutical Engineering GmbH, Graz, Austria
d University of Innsbruck, Institute of Pharmacy, Pharmaceutical Technology, Innsbruck, Austria

E. Roblegg^a,b; E. Jäger^b; A. Hodzic^b; G. Koscher^b; S. Mohr^b; A. Zimmer^a; J. Khinast^b,c. Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. - in: European Journal of Pharmaceutics and Biopharmaceutics
79/3 (2011) 635-645 (Jul 11, 2011)
a Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens University, Graz, Austria
b Research Center Pharmaceutical Engineering, Graz, Austria
c Institute for Process and Particle Engineering, Graz, University of Technology, Austria

N. Kiss^a,b; G. Brenn^a; H. Pucher^b; J. Wieser^b; S. Scheler^c; H. Jennewein^c; D. Suzzi^b; J. Khinast^b. Formation of O/W emulsions by static mixers for pharmaceutical applications. – in: Chemical Engineering Science 66 (2011) 5084-5094 (Jul 7, 2011)
a Institute of Fluid Mechanics and Heat Transfer, Graz University of Technology, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria
c Sandoz GmbH, Sandoz Development Center Austria, Kundl, Austria

A. Eitzlmayr^a; C. Petschacher^b; S. Radl^a,c; D. Suzzi^c; A. Zimmer^b; J.G. Khinast^a,c. Modeling and simulation of polyacrylic acid/protamine nanoparticle precipitation. - in: Soft Matter (2011)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Institute of Pharmaceutical Sciences, Department of PharmaceuticalTechnology, University of Graz, Austria
c Research Center Pharmaceutical Engineering GmbH, Graz, Austria

V. Mykhaylova^a; K. Dresely^a; F. Klar^a; N.A. Urbanetz^b. Carrier-free Formulation of Dry Powder Inhalates. – in: Pharmaceutical Industry (Jul 2011)
a Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria


J. M. Bolivar^a; J. Wiesbauer^a,b; B. Nidetzky^a,b,c. Biotransformations in microstructured reactors: more than flowing with the stream?. – in: Trends in Biotechnology 29/7 (2011) 333-342 (Jul 2011)
aInstitute of Biotechnology and Biochemical Engineering, Graz University of Technology, Graz, Austria
b Research Center Pharmaceutical Engineering, Graz, Austria
c Austrian Center of Industrial Biotechnology, Graz, Austria

M.S. Siraj^a; S. Radl^a,c; B.J. Glasser^b; J.G. Khinast^a,c. Effect of blade angle and particle size on powder mixing performance in a rectangular box. - in: Powder Technology 211 (2011) 100-113 (Apr 9, 2011)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Department of Chemical and Biochemical Engineering, Rutgers University, USA
c Research Center Pharmaceutical Engineering, Graz, Austria

M. Iannuccelli^a; D. Suzzi^a; B. Sirnik^a; A. Rinderhofer^b; J.G. Khinast^c. Numerical Simulation of Freeze-Thaw Biopharmaceutical Process. - in: Chemical Engineering Transactions 24 (2011) 907-912
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Zeta Biopharma GmbH, Tobelbad, Austria
c Institute of Process and Particles Technology, Graz University of Technology, Graz, Austria

K.E. Pickl^a, V. Adamek^b, R. Gorges^b, F.M. Sinner^a. Headspace-SPME-GC/MS as a simple cleanup tool for sensitive 2,6-diisopropylphenol analysis from lipid emulsions and adaptable to other matrices. – in: Journal of Pharmaceutical and Biomedical Analysis 55 (2011) 1231-1236 (Mar 17, 2011)
a Health - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria
b Research Center for Pharmaceutical Engineering GmbH, Graz, Austria


S. Karner^a, N.A. Urbanetz^a,b. The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders. – in: Journal of Aerosol Science 42 (2011) 428-445 (Mar 3, 2011)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria


C. Potamitis^a,b; P. Chatzigeorgiou^b; E. Siapi^a; K. Viras^b; T. Mavromoustakos^a,b; A. Hodzic^c,d; G. Pabst^c; F. Cacho-Nerin^c; P. Laggner^c; M. Rappolt^c: Interactions of the AT1 Antagonist valsartan with dipalmitoyl-phosphatidylcholine bilayers. – in: Biochimica et Biophysica Acta 1808 (2011) 1753 - 1763 (Feb 18, 2011).
a Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece
b Chemistry Department, National and Kapodistrian University of Athens, Greece
c Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria
d Research Center Pharmaceutical Engineering GmbH, Graz, Austria


R.J.P. Eder^a; E.K. Schmitt^a; J. Grill^a; S. Radl^a,b; H. Gruber-Woelfler^a; J.G. Khinast^a,b. Seed Loading Effects on the Mean Crystal Size of Acetylsalicylic Acid in a Continuous-Flow Crystallization Device. – in: Crystal Research and Technology 46/3 (2011) 227 - 237 (Feb 11, 2011)
a Graz University of Technology, Institute for Process and Particle Engineering, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria


C. Voura^a; M.M. Gruber^e; N. Schroedl^a; D. Strohmeier^a; B. Eitzinger^b; W. Bauer^c; G. Brenn^d; J.G. Khinast^e; A. Zimmer^f. Printable medicines: A microdosing device for producing personalised medicines. – in: Pharmaceutical Technology Europe 23 (2011) 32 - 36 (Jan 7, 2011)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Dr. Franz Feurstein GmbH, Traun, Austria
c Institute for Paper, Pulp and Fibre Technology, Graz University of Technology, Graz, Austria
d Institute of Fluid Mechanics and Heat Transfer, Graz University of Technology, Graz, Austria
e Institute of Process and Particles Technology, Graz University of Technology, Graz, Austria
f Institute of Pharmaceutical Sciences, Karl-Franzens-University, Graz, Austria

2010

B. Remy^a; J.G. Khinast^b; B.J. Glasser^a. Polydisperse Granular Flows in a Bladed Mixer: Experiments and Simulations of Cohesionless Spheres. – in: Chemical Engineering Science 66 (2011) 1811-1824 (Dec 22, 2010)
a Department of Chemical and Biochemical Engineering, Rutgers University, USA
b Institute for Process and Particle Engineering, Graz University of Technology ,Graz, Austria


M. Smikalla^a; A. Mescher^b; P. Walzel^b; N.A. Urbanetz^c. Impact of excipients on coating efficiency in dry powder coating. – in: International Journal of Pharmaceutica 405 (2011) 122-131 (Dec 8, 2010)
a Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany
b Mechanical Process Engineering, University of Technology Dortmund, Dortmund, Germany
c Research Center Pharmaceutical Engineering, Graz, Austria


J. Khinast^a,c; F. Muzzio^b. Pharmaceutical engineering science— New approaches to pharmaceutical development and manufacturing. – in: Chemical Engineering Science 65 (2010) 4-7 (Nov 1, 2010)
a Institute for Process and Particle Engineering, Graz University of Technology, Austria
b Department of Chemical and Biochemical Engineering, Rutgers University, USA
c Research Center Pharmaceutical Engineering GmbH, Graz, Austria


S. Adam^a; D. Suzzi^a; C. Radeke^a; J.G. Khinast^a,b. An integrated Quality by Design (QbD) approach towards design space definition of a blending unit operation by Discrete Element Method (DEM) simulation. – in: European Journal of Pharmaceutical Science 42 (2011) 106-115 (Nov 4, 2010)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria

C.A. Radeke^a; B.J. Glasser^b; J.G. Khinast^a,c. Large-scale Powder Mixer Simulations Using Massively Parallel GPU Architectures. – in: Chemical Engineering Science 65 (2010) 6435-6442 (Oct 1, 2010)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Rutgers, The State University of New Jersey, Department of Chemical and Biochemical Engineering, USA
c Institute for Process- and Particle Engineering, University of Technology, Graz, Austria


D.M. Koller^a; A. Posch^a; G. Hörl^a; C. Voura^a; S. Radl^b; N. Urbanetz^a,b; S.D. Fraser^a; W. Tritthart^c; F. Reiter^c; M. Schlingmann^c; J.G. Khinast^a,b. Continuous quantitative monitoring of powder mixing dynamics by near-infrared spectroscopy. – in: Powder Technology 205 (2011) 87-96 (Sep 16, 2010)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Process Engineering, Graz University of Technology, Graz, Austria
c G.L. Pharma GmbH, Lannach, Austria


S. Radl^a,b; D. Suzzi^b; J.G. Khinast^a,b. Fast Reactions in Bubbly Flows: Film Model and Micromixing Effects. – in: Industrial & Engineering Chemistry Research 49 (2010) 10715-10729 (Sep 15, 2010)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria


S. Radl^a; J.G. Khinast^a,b. Multiphase Flow and Mixing in Dilute Bubble Swarms. – in: AIChE Journal 56/9 (2010) 2421–2445 (Sep, 2010)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Research Center Pharmaceutical Engineering GmbH, Graz, Austria


D. Suzzi^a; S. Radl^a,b; J.G. Khinast^a,b. Local analysis of the tablet coating process: Impact of operation conditions on film quality. – in: Chemical Engineering Science 65 (2010) 5699-5715 (Aug 6, 2010)
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Institute for Process and Particle Engineering, University of Technology, Graz, Austria


S. Radl^a,c; E. Kalvoda^a; B.J. Glasser^b; J.G. Khinast^a,c. Mixing characteristics of wet granular matter in a bladed mixer. – in: Powder Technology 200 (2010) 171-189 (Feb 25, 2010)
a Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria
b Department of Chemical and Biochemical Engineering, Rutgers University, USA
c Research Center Pharmaceutical Engineering GmbH, Graz, Austria

S. Stegemann^a; F. Ecker^b; M. Maio^c; P. Kraahs^d; R. Wohlfart^e; J. Breitkreutz^f; A. Zimmer^g; D. Bar-Shalom^h; P. Hettrich^I; B. Broegmann^j. Geriatric drug therapy: Neglecting the inevitable majority. – in: Ageing Research Reviews 9 (2010) 384-398
a Capsugel, Bornem, Belgium
b University of Applied Sciences Fulda, Fulda, Germany
c Merck-Serono, Darmstadt, Germany
d Losan Pharma GmbH, Neuenburg, Germany
e Kneipp - Werke Würzburg, Würzburg, Germany
f Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
g Karl-Franzens-University Graz, Graz, Austria
h University of Copenhagen, Copenhagen, Denmark
i Mepha Pharma AG, Aesch, Switzerland
j Evonik Rohm GmbH, Darmstadt, Germany

S.G. Maas^a; G. Schaldach^b; P.E. Walzelb; N.A. Urbanetz^c,d. Tailoring dry powder inhaler performance by modifying carrier surface topography by spray drying. – in: Atomization and Sprays 20 (2010) 763-774
a Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany
b Department of Biochemical and Chemical Engineering, Technische Universitaet Dortmund, Germany
c Research Center Pharmaceutical Engineering GmbH, Graz, Austria
d Institute of Process and Particle Technology, Graz University of Technology, Graz, Austria

S. Radl^a; T. Tritthart^b; J.G. Khinast^a. A Novel Design for Hot-Melt Extrusion Pelletizers. – in: Chemical Engineering Science 65 (2010) 1976-1988 (Dec 3, 2009)
a Institute for Process and Particle Engineering, Graz University of Technology, Austria
b mynadis Melt ExtrusionTechnologies, Austria

2009

S. Radl^a, S. Ortner^b, R. Sungkorn^a, J.G. Khinast^a. The Engineering of Hydrogen Peroxide Decontamination Systems. – in: Journal of Pharmaceutical Innovation 4 (2009) 51-62 (Jun 16, 2009)
a Institute for Process and Particle Engineering, Graz University of Technology, Austria
c Ortner Cleanrooms Unlimited, Villach, Austria

A.N. Vasiliev^a; E.A. Gulliver^b; J.G. Khinast^c; R.E. Riman^a. Highly dispersible polymer-coated silver Nanoparticles. – in: Surface & Coatings Technology 203 (2009) 2841-2844
a Department of Materials Science and Engineering, Rutgers, The State University of New Jersey, United States
b Ferro Inc., Electronic Materials Division, New Jersey, United States
c Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, United States

D. Suzzi^a; S. Radl^b; J. Khinast^a,b. Validation of Euler-Euler and Euler-Lagrange Approaches in the Simulation of Bubble Swarms. – in: Chemical Engineering Transactions 17 (2009) 585-590
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Graz University of Technology, Institute of Process Engineering, Graz, Austria

S. Radl^a; D. Suzzi^b; J. Khinast^a,b. Assessment of Micro- and Meso Mixing in Bubble Swarms via Simulations. - in: Chemical Engineering Transactions 17 (2009) 507-512
a Research Center Pharmaceutical Engineering GmbH, Graz, Austria
b Graz University of Technology,, Institute of Process Engineering, Graz, Austria