Next-Generation
Flow Synthesis
for Pharmaceuticals
Using continuous-flow chemistry to make chemical manufacturing safer, more efficient, and more sustainable.
We develop and apply modern flow technologies to transform the way active pharmaceutical ingredients (APIs) and fine chemicals are made. By combining innovative synthetic chemistry with chemical engineering, automation, and digital process development, we bridge the gap between lab-scale discovery and robust, scalable continuous processes for industry.
What we Do
Continuous-Flow Route Development
Flow Photochemistry and Electrochemistry
Mechanochemistry
Safe Handling of Potent Compounds
Green Chemistry
Areas of Application
Safer and more robust API synthesis in flow
We design continuous-flow routes for APIs and key intermediates that improve safety, reproducibility, and process control compared to batch processing. Micro- and milli-reactors with excellent heat and mass transfer enable precise temperature control, rapid mixing, and safe handling of hazardous or unstable reagents and gases – even under demanding conditions.
Flow photochemistry and electrochemistry
We develop photochemical and electrochemical transformations in flow as greener, highly controlled alternatives to conventional redox chemistry. Tailored reactor designs and integrated monitoring help us maximize efficiency and enable scalable access to transformations that are difficult or unsafe in batch.
Mechanochemistry
We apply mechanochemical processes to minimize solvent usage and improve the sustainability of chemical manufacturing. Through mechanically driven transformations (e.g. ball milling) and low- or zero-solvent conditions, we enable highly efficient and selective reactions for APIs and intermediates.
Process intensification and multistep flow sequences
Handling hazardous chemistries and gases
PAT, automation, and digital process development
At the interface of chemistry, engineering, and digitalization, we integrate process analytical technology (PAT), automation, and data-driven optimization into our flow platforms. This enables robust control strategies, accelerated development, and efficient technology transfer.
Why partner with RCPE for Flow Synthesis?
Proven expertise across disciplines
From lab-scale innovation to industrial scale
Safer, more efficient, and more sustainable manufacturing
Strong industrial and academic network
Ready to rethink your API synthesis with continuous-flow technologies?
Contact us to explore we can help you transform challenging batch chemistries into safe, scalable, and sustainable continuous processes for API and intermediate manufacturing.
Contact
Univ.-Prof. Dr. Oliver Kappe